GCGR

Glucagon Receptor

GCGR

Related Products

GCGR (glucagon receptor) is in the G protein-coupled receptor family, that is important in controlling blood glucose levels. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

GCGR Related Products (190)
Recombinant Proteins (14)
Antibodies (3)

By Effects:	Inhibitors (12) Agonists (90) Controls (4) Antagonists (40) Activator (1) Modulators (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P0212

Neuropeptide Y, porcine	Agonist
Neuropeptide Y, porcine, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

HY-144136

GLP-1R agonist 8	Agonist
GLP-1R agonist 8 is a potent GLP-1R agonist with an EC₅₀ of < 2 nM (WO2021219019A1, compound 129a).

HY-P4672

(Met(O)27)-Glucagon (1-29) (human, rat, porcine)
(Met(O)27)-Glucagon (1-29) (human, rat, porcine) is a modified glucagon. (Met(O)27)-Glucagon (1-29) (human, rat, porcine) has the same maximum glucose-synthesizing activity in rat hepatocytes as native glucagon, but it is less potent, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor.

HY-P1144A

Oxyntomodulin (bovine, porcine) TFA	Agonist
Oxyntomodulin (bovine, porcine) TFA, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-153476

GIP/GLP-1 dual receptor agonist-1	Agonist
GIP/GLP-1 dual receptor agonist-1 is a GIP/GLP-1 dual receptor agonist. GIP/GLP-1 dual receptor agonist-1 is used in the research of metabolic disorders and fatty liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD).

HY-144033

GLP-1R agonist 1	Agonist
GLP-1R agonist 1 is a potent agonist of GLP-1R. GLP-1R agonist 1 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 1 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 4).

HY-129658

TT-OAD2 free base	Agonist
TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC₅₀ of 5 nM. TT-OAD2 free base has the potential for diabetes treatment.

HY-P3053

Helospectin I
Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.

HY-159696A

ISIS 449884 sodium	Inhibitor
ISIS 449884 sodium is a 2'-O-methoxyethyl antisense oligonucleotide that targets GCGR. ISIS 449884 sodium has an ability to reduce hepatic glucose output and lower the blood glucose level. ISIS 449884 sodium can be used for the study of type 2 diabetes mellitus (T2DM).

HY-P4843

Gastric Inhibitory Polypeptide (6-30) amide (human)
Gastric Inhibitory Polypeptide (6-30) amide (human) is an incretin hormone. Gastric Inhibitory Polypeptide (6-30) amide (human) can be used for the research of diabete.

HY-P3102A

GLP-1(32-36)amide TFA
GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

HY-19374

BAY-27-9955	Antagonist	99.68%
BAY-27-9955 is an orally active non-peptide glucagon receptor antagonist. Bay 27-9955 competitively blocks the interaction of glucagon with the human glucagonreceptor at an IC₅₀ value of 110 nM. BAY-27-9955 can be used for the study of type 2 diabetes.

HY-P4459

(Des-Gly2)-Exenatide	Control
(Des-Gly2)-Exenatide is a potential impurity of Exenatide (HY-13443).

HY-D3173

TP-α
TP-α is a glucagon-selective two-photon fluorescent probe with a K_d of 65 μM. TP-α directly interacts with glucagon to produce significant fluorescence enhancement. TP-α selectively stains viable glucagon-secreting α cells in pancreatic islets, enabling visualization of their localization, distribution and availability. TP-α is applicable to diabetes research.

HY-172673

GLP-1R agonist 31	Agonist
GLP-1R agonist 31 (Compound 1) is an amorphous glucagon-like peptide-1 receptor (GLP-1R) agonist.

HY-P1160A

Bay 55-9837 TFA
Bay 55-9837 TFA is a potent and highly selective agonist of VPAC2, with a K_d of 0.65 nM. Bay 55-9837 TFA may be a useful therapy for the research of type 2 diabetes.

HY-P1543

Exendin-3	Antagonist	98.31%
Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.

HY-128103

Glucagon receptor antagonist-7	Antagonist
Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC₅₀ of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a K_DB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels.

HY-159696B

ISIS 449884 sodium scrambled negative control	Inhibitor
ISIS 449884 sodium scrambled negative control is the sequence scrambled negative control of ISIS 449884 sodium.

HY-144133

GLP-1R agonist 5	Agonist
GLP-1R agonist 5 is a potent GLP-1R agonist with an EC₅₀ of <10 nM (WO2021259309A1, compound 35).

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GCGR

GCGR

GCGR Related Products (190)

Recombinant Proteins (14)

Antibodies (3)

GCGR Related Products (190):