SULT Inhibitor

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair.

Norethisterone caproate is an impurity of norethisterone that exhibits inhibitory activity against cytosolic sulfotransferase (SULT). Norethisterone caproate inhibits estrus in sexually mature rats during the estrous cycle, displaying long-acting progestogenic activity. Norethisterone caproate can be used in the research of reproductive system diseases.

Romolisiran is a sulfotransferase 15 (CHST15) synthesis inhibitor. CHST15 is upregulated in fibrosis (lung, liver, kidney), tumor stroma and inflammation; chondroitin sulfate chains modified by its product participate in TGF-β activation, collagen cross-linking and fibroblast activation. Romolisiran can be used to study diseases associated with fibrosis/stromal modification.