PACE4 Inhibitory peptide C23 (Synonyms: Ac-(DLeu)LLLRVK-Amba)

Name: PACE4 Inhibitory peptide C23
Brand: MedChemExpress
SKU: HY-P10816
Rating: 4.5 (0 reviews)

Cat. No.: HY-P10816 Purity: 99.40%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (K_i = 5 nM; IC₅₀ = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice.

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Custom Peptide Synthesis

PACE4 Inhibitory peptide C23 화학구조

CAS No. : 1426656-94-1

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	25 μM Compound: 2	Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay	[PMID: 30501188]
DU-145	IC₅₀	25 μM Compound: 2; C23	Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay	[PMID: 30180568]
DU-145	IC₅₀	25 μM Compound: 80	Antiproliferative activity against human DU145 cells assessed as reduction in metabolic activity after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as reduction in metabolic activity after 72 hrs by MTT assay	[PMID: 28287731]
LNCaP	IC₅₀	40 μM Compound: 2	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 30501188]
LNCaP	IC₅₀	40 μM Compound: 80	Antiproliferative activity against human LNCAP cells assessed as reduction in metabolic activity after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells assessed as reduction in metabolic activity after 72 hrs by MTT assay	[PMID: 28287731]
LNCaP	IC₅₀	45 μM Compound: 2; C23	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 30180568]

분자량

1027.35

화학식

C₅₁H₉₀N₁₄O₈

CAS No.

1426656-94-1

Appearance

Solid

Color

White to off-white

Sequence

Ac-{d-Leu}-Leu-Leu-Leu-Arg-Val-Lys-Amba

Sequence Shortening

Ac-(d-Leu)LLLRVK-Amba

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 12.5 mg/mL (12.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9734 mL	4.8669 mL	9.7338 mL
5 mM	0.1947 mL	0.9734 mL	1.9468 mL
10 mM	0.0973 mL	0.4867 mL	0.9734 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.22 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.40%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB) RP-HPLC (111 KB) MS (214 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)

References

[1]. Navals P, et al. Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host-Guest Inclusion Complex with β-Cyclodextrin. Mol Pharm. 2023 Sep 4;20(9):4559-4573. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9734 mL	4.8669 mL	9.7338 mL	24.3345 mL
	5 mM	0.1947 mL	0.9734 mL	1.9468 mL	4.8669 mL
	10 mM	0.0973 mL	0.4867 mL	0.9734 mL	2.4334 mL

PACE4 Inhibitory peptide C23 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PACE4 Inhibitory peptide C231426656-94-1Ac-(DLeu)LLLRVK-AmbaBacterialPACE4antiproliferative effectsPCa cell linesInhibitorinhibitorinhibit

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PACE4 Inhibitory peptide C23 (Synonyms: Ac-(DLeu)LLLRVK-Amba)

고객리뷰

PACE4 Inhibitory peptide C23 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

PACE4 Inhibitory peptide C23 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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