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Cat. No.: HY-156407

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Adam-20-S

Adam-20-S is a potent glucosinolate sulfatase inhibitor with an IC₅₀ value of 9.04 μg/mL. Adam-20-S impaires glucosinolate metabolism to produce more toxic isothiocyanates in P. xylostella.

For research use only. We do not sell to patients.

CAS No.: 2413880-52-9
Formula: C₁₇H₂₁FN₂O₄S
Molecular Weight:368.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Adam-20-S Chemical Structure

CAS No.: 2413880-52-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀：9.04 μg/mL^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
JEG-3	IC₅₀	67.7 nM Compound: 1p	Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis	[PMID: 32173116]
T47D	IC₅₀	3.4 μM Compound: 1p	Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay	[PMID: 32173116]

Chemical Information

CAS No. 2413880-52-9
Molecular Weight 368.42
Formula C₁₇H₂₁FN₂O₄S
SMILES

FC1=CC(C(NC2(C3)CC4CC3CC(C2)C4)=O)=CC=C1OS(N)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dehong L,et al. Synthesis and Biological Activity of Sulfamate-Adamantane Derivatives as Glucosinolate Sulfatase Inhibitors. 2023 Oct 25;71(42):15476-15484. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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