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Cat. No.: HY-187714

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α-Glucosidase-IN-123

α-Glucosidase-IN-123, a hybrid derivative of baicalein and cinnamic acid, acts as an inhibitor of α-glucosidase. α-Glucosidase-IN-123 enhances glucose uptake in insulin-resistant hepatocytes without significant cytotoxicity. α-Glucosidase-IN-123 exhibits lipase inhibitory activity and DPPH free radical scavenging activity, and it can be used in the research of type 2 diabetes.

For research use only. We do not sell to patients.

Formula: C₂₇H₂₀O₉
Molecular Weight:488.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Glucosidase-IN-123 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IC₅₀ & Target^[1]

α‑glucosidase

In Vitro

α-Glucosidase-IN-123 (compound 7i) at 50 μM exhibits an inhibition rate of 21.55% against α-glucosidase, with weaker activity than its parent compound Baicalein (HY-N0196). It inhibits lipase with an inhibition rate of 22.60%, showing stronger activity than Baicalein, and causes no significant cytotoxicity against HepG2 cells^[1].
α-Glucosidase-IN-123 (500 μM) exhibits an IC₅₀ of 207.7 μM for DPPH radical scavenging, with antioxidant activity weaker than that of Baicalein^[1].
α-Glucosidase-IN-123 (0.1-10 μM) increases the glucose consumption rate in insulin-resistant HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 488.44
Formula C₂₇H₂₀O₉
SMILES

O=C(OC1=CC(OC(C2=CC=CC=C2)=CC3=O)=C3C(O)=C1O)/C=C/C4=CC(OC)=C(OC(C)=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhao X, et al. A Novel Series of Flavone-Cinnamic Acid Hybrid Derivatives as Hypoglycemic Agents: Design, Synthesis, and Activity Studies. Chemistry & biodiversity. 2026 Jul;23(7):e71501.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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