(αS)-Lopinavir metabolite M-3/M-4
(αS)-Lopinavir metabolite M-3/M-4 is an HIV protease inhibitor with a Ki of 1.2 pM and antiviral activity against HIV. (αS)-Lopinavir metabolite M-3/M-4 inhibits HIV protease activity. (αS)-Lopinavir metabolite M-3/M-4 can be used for the research of human immunodeficiency virus (HIV) infection.
For research use only. We do not sell to patients.
- CAS No.: 357275-54-8
- Formula: C37H48N4O6
- Molecular Weight:644.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | EC50 |
2.31 μM
Compound: M-3/M-4
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Antiviral activity against HIV in presence of 50% human serum in MT-4 cell was determined
Antiviral activity against HIV in presence of 50% human serum in MT-4 cell was determined
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[PMID: 11378352] |
In Vitro
(αS)-Lopinavir metabolite M-3/M-4 inhibits HIV replication in MT-4 cells (in vitro in the presence of 50% human serum) with an EC50 of 2.31 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 357275-54-8
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Molecular Weight 644.81
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Formula C37H48N4O6
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SMILES
[C@@H](C(N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@H](CC2=CC=CC=C2)NC(COC3=C(C)C=CC=C3C)=O)O)=O)([C@@H](C)C)N4C(=O)NC(O)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(αS)-Lopinavir metabolite M-3/M-4 Related Classifications
HY-W700110 Related Classifications
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