Aminooxy-PEG1-propargyl
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Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1895922-69-6
- Formula: C5H9NO2
- Molecular Weight:115.13
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1895922-69-6
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Appearance Liquid (Density: 1.035 g/cm3)
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Molecular Weight 115.13
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Formula C5H9NO2
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Color Colorless to light yellow
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SMILES
NOCCOCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (868.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.6858 mL | 43.4292 mL | 86.8583 mL | 217.1458 mL |
| 5 mM | 1.7372 mL | 8.6858 mL | 17.3717 mL | 43.4292 mL | |
| 10 mM | 0.8686 mL | 4.3429 mL | 8.6858 mL | 21.7146 mL | |
| 15 mM | 0.5791 mL | 2.8953 mL | 5.7906 mL | 14.4764 mL | |
| 20 mM | 0.4343 mL | 2.1715 mL | 4.3429 mL | 10.8573 mL | |
| 25 mM | 0.3474 mL | 1.7372 mL | 3.4743 mL | 8.6858 mL | |
| 30 mM | 0.2895 mL | 1.4476 mL | 2.8953 mL | 7.2382 mL | |
| 40 mM | 0.2171 mL | 1.0857 mL | 2.1715 mL | 5.4286 mL | |
| 50 mM | 0.1737 mL | 0.8686 mL | 1.7372 mL | 4.3429 mL | |
| 60 mM | 0.1448 mL | 0.7238 mL | 1.4476 mL | 3.6191 mL | |
| 80 mM | 0.1086 mL | 0.5429 mL | 1.0857 mL | 2.7143 mL | |
| 100 mM | 0.0869 mL | 0.4343 mL | 0.8686 mL | 2.1715 mL |
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