Anti-Mouse CD28 Antibody (37.51)
Based on 2 publication(s) in Google Scholar
Anti-Mouse CD28 Antibody (37.51) is an agonistic agonistic CD28-specific antibody derived from the host Syrian Hamster. Anti-Mouse CD28 Antibody (37.51) partially prevents lethal graft-versus-hostdisease (GVHD) by selective depletion of alloreactive T cells in mice.
For research use only. We do not sell to patients.
- Purity: ≥95.0%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse CD28 Antibody (37.51)
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Biological Activity
Syrian hamster IgG2
Mouse
CD28
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lethally irradiated (1200 cGy) B10.BR mice were given transplants of 15 x 106 T cell–depleted marrow cells plus 25 x 106 splenocytes from B6 donors[1]
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Dosage:20 μg and 100 μg for a single dose, 20 μg every other day for 8 times
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Administration:Intraperitoneally injection
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Result:Delayed the onset of GVHD and improved survival after a single 20-μg dose.
Protected 60% of mice from lethal acute GVHD after a single 100-μg dose.
Resulted of 20 μg administered every other day for 8 days similar to those with a single 100-μg dose.
Decreased donor CD4+ cells and CD8+ cells.
Reduced numbers of T- and B- cells in the spleen.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
in vitro T cell stimulation/activation; in vivo CD28 blockade
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD28 Antibody (37.51)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Commun (Lond)
Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein. [Abstract]2025 Mar;45(3):218-244. PMID: 39698847 -
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD28 Antibody (37.51) Related Classifications
HY-P99123 Related Classifications
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