Anti-Mouse CD45RB Antibody (MB23G2)
Anti-Mouse CD45RB Antibody (MB23G2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45RB. Anti-Mouse CD45RB Antibody (MB23G2) blocks CD45RB and induces transplantation tolerance. Anti-Mouse CD45RB Antibody (MB23G2) can be used for the researches of infection, immunology and metabolic disease, such as diabetes and Mem71 (H3N1) virus-infection.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2a kappa
Mouse
The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anti-Mouse CD45RB Antibody (MB23G2) (200 μg, i.p., 1 day prior to infection and thereafter every 3 days) delays viral clearance in Mem71 (H3N1) virus-infected mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin (HY-13753)-induced diabetic mice with Islet grafts[1]
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Dosage:100 μg
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Administration:Intravenously injection, at days -1, 0, and 5
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Result:Became normoglycemic within 3 days and prolonged survival.
Reduced IL-2, IFN-α,and IL-4 mRNA amounts.
Decreased white blood cell counts on day 3 and 7.
Reduced the CD45RBbright population for a week, but the population had already partially returned 5 days after the last injection.
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Animal Model:Mem71 (H3N1) virus-infected mice models[2]
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Dosage:200 μg
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Administration:Intraperitoneally injection, 1 day prior to infection and thereafter every 3 days
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Result:Showed delayed viral clearance.
Showed fewer T cells were present in both MLN and lung.
Reduced total influenza-specific CD8+ T cells.
Delayed the humoral response.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo anti-CD45RB_mediated tolerance induction; in vivo pre-mNK cell depletion
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse CD45RB Antibody (MB23G2)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD45RB Antibody (MB23G2) Related Classifications
HY-P990267 Related Classifications
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