2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis Topoisomerase
  4. Anti-MRSA agent 7

Anti-MRSA agent 7 (Compound 12) is a potent antibacterial agent. Anti-MRSA agent 7 inhibits S. aureus DNA gyrase, E. coli DNA gyrase, S. aureus topo IV and E. coli topo IV with IC50s of 0.185, 0.365, 0.341 and 0.059 μM, respectively.

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Anti-MRSA agent 7

Anti-MRSA agent 7 Estructura química

No. CAS : 3049205-78-6

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Anti-MRSA agent 7 Related Antibodies

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Topoisomerase Topo I Topo II DNA gyrase

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Descripciòn

Anti-MRSA agent 7 (Compound 12) is a potent antibacterial agent. Anti-MRSA agent 7 inhibits S. aureus DNA gyrase, E. coli DNA gyrase, S. aureus topo IV and E. coli topo IV with IC50s of 0.185, 0.365, 0.341 and 0.059 μM, respectively[1].

IC50 & Target[1]

TOPO IV

0.059 μM (IC50, E. coli )

TOPO IV

0.341 μM (IC50, S. aureus)

DNA gyrase

0.185 μM (IC50, S. aureus)

DNA gyrase

0.365 μM (IC50, E. coli )

In Vitro

Anti-MRSA agent 7 (Compound 12) shows a dose-dependent killing efficacy achieving bactericidal effect against planktonic methicillin-resistant S. aureus (ATCC 43300) at 8 × MIC after 8 h of treatment, after which re-growth occurs[1].
Antimicrobial activity of Anti-MRSA agent 7 (Compound 12) against a panel of Gram-positive and Gram-negative bacterial pathogens[1]

Strain S. aureus (ATCC 29213) MRSAQA-12.1 E. coli N43 (CGSC# 5583) MRSA QA-11.7 MRSA QA-11.2 E. faecalis DRK 057 E. coli (ATCC 25922)
MIC (μM) 0.03 0.03 0.06 0.06 0.124 4.07 252
Strain E. coli D22 A. baumannii E. coli ESBL QA:11.3 K. pneumoniae S. alachua RDK 030c P. aeruginosa RDK 184
MIC (μM) 252 252 >252 >252 >252 >252

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 7 Related Antibodies
In Vivo

Anti-MRSA agent 7 (Compound 12; 20 and 40 mg/kg; i.p.; QID for 1 day) demonstrates high in vivo efficacy in MRSA neutropenic mouse thigh infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 female mice, MRSA neutropenic mouse thigh infection model[1]
Dosage: 20 and 40 mg/kg
Administration: IP/QID (four times a day) at 2, 8, 14, and 20 h post infection
Result: Demonstrated inhibition of bacterial growth in a dose dependent manner.
Peso molecular

508.31

Fòrmula

C22H20BrF2N3O4
No. CAS
SMILES

COC1=NC2=C(N=CC=C2OC[C@H]3CC[C@@H](CO3)NC(C4=CC(F)=C(C(F)=C4)Br)=O)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Anti-MRSA agent 7 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MRSA agent 73049205-78-6BacterialDNA/RNA SynthesisTopoisomeraseInhibitorinhibitorinhibit

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Anti-MRSA agent 7
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