Antibacterial agent 127 

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent^[1].

Bacterial^[1]

Antibacterial agent 127 (Compound 23) (0-64 μg/mL; 20 h) shows antibacterial activity with MICs of 0.063, 0.063, 0.063, 0.25, 32 and 64 μg/mL against MSSA ATCC29213, MSSA ATCC25923, MRSAb, MRSEb, E.coli ATCC25922 and S.pullorum, respectively. And shows low cytotoxicity to RAW 264.7 cells (IC₅₀＞100 μM)^[1].
Antibacterial agent 127 shows good metabolic stability (t_1/2 = 3.25 min in rat liver microsomes)^[1].
Antibacterial agent 127 exhibits moderate inhibition effect on CYP3A4 (Midazolam) and CYP3A4 (Testosterone), with IC₅₀ values of 2.64 and 1.94 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 127 (Compound 23) (50 mg/kg; i.p.; single dose) inhibits MRSA effectively in a mouse thigh infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

527.68

C₂₈H₃₇N₃O₅S

C[C@]([C@@H](O)[C@@H]1C)(C[C@@H](OC(CSC(N2)=NC3=C(C=CN3)C2=O)=O)[C@@]4(C)[C@@]5([H])[C@]1(CCC5=O)CC[C@H]4C)C=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Deng Y, et al. Antibacterial activity evaluation of pleuromutilin derivatives with 4(3H)-quinazolinone scaffold against methicillin-resistant Staphylococcusaureus. Eur J Med Chem. 2022 Nov 23;246:114960.  [Content Brief]