ANGPTL7/ CDT6 Antibody
(Synonyms: CDT6, UNQ313/PRO356, ANGPTL7, Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein)ANGPTL7/ CDT6 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ANGPTL7.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
ANGPTL7/ CDT6 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ANGPTL7.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 40 kDa
Synthetic peptide corresponding to the C-term region of human ANGPTL7.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ANGPTL7/ CDT6 is a Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency[1][2].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Highly expressed in the cornea (at protein level). Expression is restricted to the stromal layer. Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera.
Induction: Expression is up-regulated by dexamethasone. -
Isoforms & Post-Translational Modification
ANGPTL7/ CDT6 has an amino acid length of 346, molecular weight is 40018 Da.
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Subunit
Homotetramer; disulfide-linked
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SwissProt ID
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Synonyms
CDT6, UNQ313/PRO356, ANGPTL7, Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein
Documentation
References
[1]. Comes N, et al. Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma. Genes Cells. 2011 Feb;16(2):243-59. [Content Brief]
[2]. Toyono T, et al. Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea. PLoS One. 2015;10(1):e0116838. [Content Brief]
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