ANGPTL7 - angiopoietin like 7 Gene

Also Known as AngX; CDT6; dJ647M16.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10218

About ANGPTL7

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,189,355-11,195,981 (from NCBI)

This gene has 2 transcripts (splice variants), 316 orthologues and 25 paralogues. Broad expression in heart (RPKM 2.5), gall bladder (RPKM 2.2) and 15 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ANGPTL7 Products (1)

mRNA	Protein	Name
NM_021146.4	NP_066969.1	angiopoietin-related protein 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	11682471	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	25622036	GOA
involved in regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	21199193	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11682471	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
angiopoietin-related protein 7	angiopoietin-like factor (CDT6)

Recombinant ANGPTL7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7509	ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His)	O43827 (Q27-P346)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78932	ANGPTL7/Angiopoietin-related 7 Protein, Human (Biotinylated, HEK293, mFc-Avi)	O43827 (Q27-P346)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700852	ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc)	O43827 (Q27-P346)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700955	ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His-Avi)	O43827 (Q27-P346)	≥ 95%, as determined by reducing SDS-PAGE.

ANGPTL7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811028	ANGPTL7/ CDT6 Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Steroid-Induced Glaucoma	Corticosteroid-Induced Glaucoma
Schnyder Corneal Dystrophy	Schnyder Crystalline Corneal Dystrophy SCCD Corneal Dystrophy, Crystalline, Of Schnyder Corneal Dystrophy, Schnyder Type Corneal Dystrophy Crystalline Of Schnyder Crystalline Stromal Dystrophy Hereditary Crystalline Stromal Dystrophy Of Schnyder Scd Corneal Dystrophy, Schnyder Schnyder Crystalline Dystrophy Sine Crystals Dystrophy, Corneal, Crystalline, Schnyder
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00696	ANGPTL7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17280	Angptl7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23735	Angptl7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ANGPTL7	VGNC	VGNC:25895
Canis familiaris	ANGPTL7	VGNC	VGNC:37863
Macaca mulatta	ANGPTL7	VGNC	VGNC:69683
Rattus norvegicus	ANGPTL7	RGD	RGD:7553363
Felis catus	ANGPTL7	VGNC	VGNC:59783
Mus musculus	ANGPTL7	MGD	MGI:3605801
Others	ANGPTL7	NCBI