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  5. Aprataxin Antibody (YA2138)(PBS only)

Aprataxin Antibody (YA2138)(PBS only)

Cat. No.: HY-P82393A
User Guide for Antibodies Technical Support

Aprataxin Antibody (YA2138) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aprataxin.

For research use only. We do not sell to patients.

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50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

Aprataxin Antibody (YA2138) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aprataxin.
Host

Rabbit
Molecular Weight
Predicted band size: 41 kDa;
Observed band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human Aprataxin aa147-160.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Purity Affinity Purified Conjugation Non-conjugated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15044383, PubMed:15380105, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)
Subcellular Localization：Nucleus, nucleoplasm; Nucleus, nucleolus; Cytoplasm
Expression：
Tissue_specificity:Widely expressed; detected in liver, kidney and lymph node (at protein level) (PubMed:14755728) . Isoform 1 is highly expressed in the cerebral cortex and cerebellum, compared to isoform 2 (at protein level) (PubMed:14755728) . Widely expressed; detected tH2O2ghout the brain, in liver, kidney, skeletal muscle, fibroblasts, lymphocytes and pancreas (PubMed:11586299, PubMed:11586300, PubMed:15276230)
Isoforms & Post-Translational Modification：Q7Z2E3 has 13 isomers: Q7Z2E3-1: 40740 Da (predicted); Q7Z2E3-2: 19715 Da (predicted); Q7Z2E3-3: 32901 Da (predicted); Q7Z2E3-4: 29108 Da (predicted); Q7Z2E3-5: 33125 Da (predicted); Q7Z2E3-6: 13305 Da (predicted); Q7Z2E3-7: 39104 Da (predicted); Q7Z2E3-8: 38589 Da (predicted); Q7Z2E3-9: 33294 Da (predicted); Q7Z2E3-10: 34761 Da (predicted); Q7Z2E3-11: 34930 Da (predicted); Q7Z2E3-12: 5828 Da (predicted); Q7Z2E3-13: 21389 Da (predicted).
Subunit：Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53 (PubMed:14755728, PubMed:15044383, PubMed:15380105, PubMed:16777843). Interacts with NCL (PubMed:15044383, PubMed:16777843). Interacts (via FHA-like domain) with MDC1 (phosphorylated) (PubMed:20008512)
Research Field

Epigenetics and Nuclear Signaling
Synonyms
AOA; AOA1; AXA1; EAOH; EOAHA; FHA-HIT
Documentation
User Guide for Antibodies (1077 KB)
References

Aprataxin Antibody (YA2138)(PBS only) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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