AURKC Antibody (YA8124)

Cat. No.: HY-P88440: Data Sheet COA
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AURKC Antibody (YA8124) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AURKC.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

AURKC Antibody (YA8124) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AURKC.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 35.6 kDa

Species Reactivity

Human

SwissProt ID

Q9UQB9

Immunogen

Full-length protein expressed in 293T cell transfected with human AURKC expression vector

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'

Subcellular Localization：Nucleus,Chromosome,Chromosome, centromere,Cytoplasm, cytoskeleton, spindle

Expression：
Tissue_Specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase
Induction: Expression is cell cycle-regulated, with an increase during G2 and M phases

Isoforms & Post-Translational Modification：Q9UQB9 has three isomers: Q9UQB9-1: 35591 Da (predicted); Q9UQB9-2: 32187 Da (predicted); Q9UQB9-3: 33672 Da (predicted).

Subunit：Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP

Synonyms

AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90; SPGF5; STK13

Documentation

Select Batch:

Data Sheet (231 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)