Caveolin-1 Antibody (YA1782)(PBS only)

Cat. No.: HY-P82037A: Data Sheet User Guide for Antibodies
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Caveolin-1 Antibody (YA1782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Caveolin-1 Antibody (YA1782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.

Host

Rabbit

분자량

Predicted band size: 20 kDa;

Observed band size: 20 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q03135

Gene ID

857 [NCBI]

Immunogen

Recombinant protein of human Caveolin-1 aa2-100.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
IHC-F IHC-F: Immunohistochemistry-Frozen	1:50-1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
IP IP: Immunoprecipitation	1:20

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)

Subcellular Localization：Golgi apparatus membrane; Peripheral membrane protein; Cell membrane; Peripheral membrane protein; Membrane, caveola; Peripheral membrane protein; Membrane raft; Golgi apparatus, trans-Golgi network

Expression：
Tissue_specificity:skeletal muscle, liver, stomach, lungs, kidneys, and heart (protein levels) . Expressed in the brain.

Isoforms & Post-Translational Modification：Q03135 has 2 isomers: Q03135-1: 20472 Da (predicted); Q03135-2: 17023 Da (predicted).
Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination (PubMed:21822278). Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation (PubMed:23335559). Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response (PubMed:28593998);The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated;Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress

Subunit：Homooligomer (PubMed:25588833). Interacts with GLIPR2 (PubMed:11865038). Interacts with NOSTRIN (PubMed:16807357)

Research Field

Cardiovascular

Synonyms

CAV1; CAV; Caveolin-1

각종 서류

User Guide for Antibodies (1077 KB)