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  5. Caveolin-1 Antibody (YA1782)(PBS only)

Caveolin-1 Antibody (YA1782)(PBS only)

製品番号: HY-P82037A
User Guide for Antibodies Technical Support

Caveolin-1 Antibody (YA1782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Caveolin-1 Antibody (YA1782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.
Host

Rabbit
分子量
Predicted band size: 20 kDa;
Observed band size: 20 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human Caveolin-1 aa2-100.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
IHC-F
IHC-F: Immunohistochemistry-Frozen
1:50-1:100
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
IP
IP: Immunoprecipitation
1:20
純度 Affinity Purified Conjugation Non-conjugated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)
Subcellular Localization：Golgi apparatus membrane; Peripheral membrane protein; Cell membrane; Peripheral membrane protein; Membrane, caveola; Peripheral membrane protein; Membrane raft; Golgi apparatus, trans-Golgi network
Expression：
Tissue_specificity:skeletal muscle, liver, stomach, lungs, kidneys, and heart (protein levels) . Expressed in the brain.
Isoforms & Post-Translational Modification：Q03135 has 2 isomers: Q03135-1: 20472 Da (predicted); Q03135-2: 17023 Da (predicted).
Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination (PubMed:21822278). Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation (PubMed:23335559). Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response (PubMed:28593998);The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated;Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress
Subunit：Homooligomer (PubMed:25588833). Interacts with GLIPR2 (PubMed:11865038). Interacts with NOSTRIN (PubMed:16807357)
Research Field

Cardiovascular
Synonyms
CAV1; CAV; Caveolin-1
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Caveolin-1 Antibody (YA1782)(PBS only) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Caveolin-1 Antibody (YA1782)(PBS only)
製品番号:
HY-P82037A
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