CD35 Antibody (YA5699)
(Synonyms: CD35, C3BR, CR1, Complement receptor type 1, C3b/C4b receptor)CD35 Antibody (YA5699) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD35.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-400 | 1:500-5000 |
Product Details
CD35 Antibody (YA5699) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD35.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 250 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 223 kDa
Synthesized peptide derived from human CD35 AA range: 300-400
affinity chromatography.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD35 is a Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells; (Microbial infection) Acts as a receptor for Epstein-Barr virus[1][2][3][4].
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:It is found on erythrocytes, some T cells, mature B cells, follicular dendritic cells, monocytes, and granulocytes. -
Subunit
Interacts (via Sushi 1 and Sushi 2 domains) with complement factor C4b (PubMed:2972794, PubMed:8175757). Interacts (via Sushi 8 and Sushi 9 domains) with complement factor C3b (PubMed:2972794, PubMed:8175757). Interacts (via Sushi 24 and Sushi 25 domains) with MBL2 (PubMed:23460739, PubMed:29563915). Interacts with FCN2 (PubMed:2972794). Interacts (via Sushi 24 and Sushi 25 domains) with C1QA (PubMed:29563915, PubMed:9324355). Interacts with CR2 (PubMed:1708808)
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SwissProt ID
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Synonyms
CD35, C3BR, CR1, Complement receptor type 1, C3b/C4b receptor
Documentation
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