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Cat. No.: HY-P80058

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CD41 Antibody (YA535)

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CD41 Antibody (YA535) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD41.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P
Reactivity :
Human

Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio	1:500-1:2000	1:50-1:200

Product Details

Description

CD41 Antibody (YA535) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD41.

Host Rabbit
Clonality Recombinant, Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 128 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 113 kDa

Species Reactivity Database

Entrez Gene: 3674 Human

SwissProt: P08514 Human

OMIM: 273800 Human

Immunogen

Synthetic peptide corresponding to Human CD41.AA range:41-74.

Sensitivity

Endogenous

Purification

Protein A affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3102287

Product Properties

Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity)
Subcellular Localization

Membrane; Single-pass type I membrane protein
Expression

Tissue_specificity:Isomers 1 and 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. They were not detected in Jurkat cells or the U937 cell line (PubMed: 2351656) . Isomer 3 is expressed in prostate adenocarcinoma and various erythroleukemia, prostate adenocarcinoma, and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B, and WM35. It was not detected in platelets or normal prostate tissue (protein level) (PubMed: 9809974) .
Isoforms & Post-Translational Modification

P08514 has 3 isomers: P08514-1: 113377 Da (predicted); P08514-2: 109574 Da (predicted); P08514-3: 103218 Da (predicted).
Cleaved by ELANE; the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3
Subunit

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond.
SwissProt ID

P08514
Gene ID

3674 [NCBI]
Research Field

Cardiovascular