CHREBP/MLXIPL Antibody (YA7086)(PBS only)
(Synonyms: BHLHD14, MIO, WBSCR14, MLXIPL, Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, Williams-Beuren syndrome chromosomal region 14 protein, bHLHd14, WS-bHLH)CHREBP/MLXIPL Antibody (YA7086) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHREBP/MLXIPL.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
CHREBP/MLXIPL Antibody (YA7086) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHREBP/MLXIPL.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 93.1kDa;
Purified recombinant fragment of human MLXIPL (AA: 18-143) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CHREBP/MLXIPL binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in liver, heart, kidney, cerebellum and intestinal tissues -
Isoforms & Post-Translational Modification
Q9NP71 has 6 isomers: Q9NP71-1: 93073 Da (predicted); Q9NP71-2: 90924 Da (predicted); Q9NP71-3: 92842 Da (predicted); Q9NP71-4: 90694 Da (predicted); Q9NP71-5: 62026 Da (predicted); Q9NP71-6: 78360 Da (predicted).
Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity -
Subunit
Binds DNA as a heterodimer with MLX/TCFL4
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SwissProt ID
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Synonyms
BHLHD14, MIO, WBSCR14, MLXIPL, Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, Williams-Beuren syndrome chromosomal region 14 protein, bHLHd14, WS-bHLH
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