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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Complement factor B Antibody (YA2984)

Complement factor B Antibody (YA2984)

Cat. No.: HY-P83239
User Guide for Antibodies Technical Support

Complement factor B Antibody (YA2984) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complement factor B.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Complement factor B Antibody (YA2984) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complement factor B.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 86 kDa;
Observed band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Complement factor B aa700-764.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:3638964, PubMed:624565, PubMed:6554279, PubMed:6919543, PubMed:9748277). The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases (PubMed:3638964, PubMed:624565, PubMed:6554279, PubMed:6919543, PubMed:9748277). CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases (PubMed:6769474, PubMed:9748277); Serine protease component of the complement C3 and C5 convertase complexes of the alternative complement pathway (PubMed:30643019, PubMed:3638964, PubMed:624565, PubMed:6554279, PubMed:6919543). Following cleavage and activation by factor D (CFD), forms the C3 convertase together with complement C3b (PubMed:3638964, PubMed:624565, PubMed:6554279, PubMed:6919543, PubMed:9748277). As part of the C3 convertase, cleaves and activates C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways (PubMed:3638964, PubMed:624565, PubMed:6554279, PubMed:6919543, PubMed:9748277). When an additional complement C3b molecule binds to the C3 convertase, forms the C5 convertase, which cleaves and activates C5 into C5a anaphylatoxin and C5b component of the membrane attack complex (PubMed:30643019, PubMed:624565, PubMed:6554279); Involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes
Subcellular Localization：Secreted; Cell surface
Isoforms & Post-Translational Modification：P00751 has 2 isomers: P00751-1: 85533 Da (predicted); P00751-2: 68872 Da (predicted).
Cleaved by CFD following activation of the alternative complement system, generating Ba and Bb chains (PubMed:21205667, PubMed:6769474, PubMed:874324, PubMed:9748277). Cleavage and activation takes place when CFB is already associated with complement C3b (PubMed:21205667)
Subunit：Monomer (PubMed:19574954). Interacts with complement C3b; this interaction is dependent on the presence of Mg(2+) (PubMed:28264884, PubMed:31507604)
Database

Entrez Gene: 629 Human

SwissProt: P00751 Human

OMIM: 615489 Human

Research Field

Immunology
Synonyms
C3/C5 convertase; Complement factor B; PBF2; Properdin factor B
Documentation
User Guide for Antibodies (1077 KB)

Complement factor B Antibody (YA2984) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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