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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Cytochrome P450 24A1 Antibody (YA2121)

Cytochrome P450 24A1 Antibody (YA2121)

Cat. No.: HY-P82376
COA
SDS
User Guide for Antibodies Technical Support

Cytochrome P450 24A1 Antibody (YA2121) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 24A1.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

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  • 제품 설명

제품 설명

Cytochrome P450 24A1 Antibody (YA2121) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 24A1.
Host

Rabbit
Clonality

Recombinant, Monoclonal
분자량
Predicted band size: 59 kDa;
Observed band size: 59 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human CYP24A1 aa100-150/514.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Background
Function：A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:11012668, PubMed:15574355, PubMed:16617161, PubMed:24893882, PubMed:29461981, PubMed:8679605). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:15574355, PubMed:24893882). With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605). Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605)
Subcellular Localization：Mitochondrion
Isoforms & Post-Translational Modification：Q07973 has 3 isomers: Q07973-1: 58875 Da (predicted); Q07973-2: 51207 Da (predicted); Q07973-3: 43051 Da (predicted).
Database

Entrez Gene: 1591 Human

SwissProt: Q07973 Human

OMIM: 143880 Human

Research Field

Cardiovascular
Synonyms
CYP24A1; CYP24; 1; 25-dihydroxyvitamin D(3) 24-hydroxylase; mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24
각종 서류
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

Cytochrome P450 24A1 Antibody (YA2121) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
Cytochrome P450 24A1 Antibody (YA2121)
Cat. No.:
HY-P82376
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