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Cat. No.: HY-P87832

Cytokeratin 10 Antibody (YA7517)

Cytokeratin 10 Antibody (YA7517) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Cytokeratin 10.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:200-1:1000	1:2000-1:10000	1:200-1:1000	1:5000-1:20000

Description

Cytokeratin 10 Antibody (YA7517) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Cytokeratin 10.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 59 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 59 kDa

Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG,Kappa

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Cytokeratin 10 plays a role in the establishment of the epidermal barrier on plantar skin. Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium|(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization|(Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur
Subcellular Localization

Secreted, extracellular space,Cell surface,Cytoplasm
Expression

Tissue_Specificity: Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498). Localized on the surface of desquamated nasal epithelial cells (at protein level) (PubMed:12427098)
Induction: Repressed in keratinocytes by all-trans retinoic acid (ATRA), via reduction of mRNA stability
Isoforms & Post-Translational Modification

P13645: 584 amino acids, molecular weight 58827 Da.
Subunit

Heterotetramer of two type I and two type II keratins
SwissProt ID

P13645