Factor IX Antibody (YA10003)
(Synonyms: Coagulation factor IX, Christmas factor, Plasma thromboplastin component, PTC, F9)Factor IX Antibody (YA10003) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Factor IX.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
Factor IX Antibody (YA10003) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Factor IX.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Synthetic peptide corresponding to human Factor IX protein.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Factor IX is a Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa[1][2][3][4][5][6][7].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Detected in blood plasma (at protein level). Synthesized primarily in the liver and secreted in plasma. -
Isoforms & Post-Translational Modification
Factor IX has 2 isoforms, P00740-1: amino acid length is 461, molecular weight is 51778 Da (predicted); P00740-2: amino acid length is 423, molecular weight is 47618 Da (predicted).Activated by factor XIa, which excises the activation peptide (PubMed:1730085, PubMed:9169594, PubMed:22961984). The propeptide can also be removed by snake venom protease (PubMed:20004170, PubMed:20080729). Activated by coagulation factor VIIa-tissue factor (F7-F3) complex in calcium-dependent manner (PubMed:271951)
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Subunit
Heterodimer of a light chain and a heavy chain; disulfide-linked.
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SwissProt ID
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Synonyms
Coagulation factor IX, Christmas factor, Plasma thromboplastin component, PTC, F9
Documentation
[1]. de la Salle C, et al. The Arg-4 mutant factor IX Strasbourg 2 shows a delayed activation by factor XIa. Nouv Rev Fr Hematol (1978). 1993;35(5):473-80. [Content Brief]
[2]. Suehiro K, et al. Blood clotting factor IX BM Nagoya. Substitution of arginine 180 by tryptophan and its activation by alpha-chymotrypsin and rat mast cell chymase. J Biol Chem. 1989 Dec 15;264(35):21257-65. [Content Brief]
[3]. Wang S, et al. Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J Med Chem. 2010 Feb 25;53(4):1473-82. [Content Brief]
[4]. Wang S, et al. Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem. 2010 Feb 25;53(4):1465-72. [Content Brief]
[5]. Rawala-Sheikh R, et al. Role of gamma-carboxyglutamic acid residues in the binding of factor IXa to platelets and in factor-X activation. Blood. 1992 Jan 15;79(2):398-405. [Content Brief]
[6]. Simioni P, et al. X-linked thrombophilia with a mutant factor IX (factor IX Padua). N Engl J Med. 2009 Oct 22;361(17):1671-5. [Content Brief]
[7]. Cao Q, et al. Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface. Nature. 2025 Mar;639(8055):816-824. [Content Brief]
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