FAM134B Antibody (YA6567)

Art. -Nr.: HY-P86874: Data Sheet User Guide for Antibodies
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FAM134B Antibody (YA6567) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAM134B.

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100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

FAM134B Antibody (YA6567) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAM134B.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molekulargewicht

Predicted band size: 55 kDa;

Observed band size: 70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9H6L5

Gene ID

54463 [NCBI]

Immunogen

Recombinant protein within human FAM134B aa 318-497 / 497.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100

Reinheit	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720)|(Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449)

Subcellular Localization：Golgi apparatus, cis-Golgi network membrane,Endoplasmic reticulum membrane,Endoplasmic reticulum membrane

Expression：
Tissue_Specificity: Overexpressed in esophageal squamous cell carcinoma (PubMed:17487424)

Isoforms & Post-Translational Modification：Q9H6L5 has 2 isomers: Q9H6L5-1: 54681 Da (predicted); Q9H6L5-2: 39317 Da (predicted).
Phosphorylation at Ser-151 by CAMK2B enhances oligomerization and membrane scission and reticulophagy activity

Subunit：Homooligomer; oligomerization is enhanced following endoplasmic reticulum stress and is mediated by the reticulon homology domain (PubMed:31930741)

Synonyms

Reticulophagy regulator 1 RETREG1 Reticulophagy receptor 1 FAM134B JK1

Dokumentation

User Guide for Antibodies (1077 KB)