FAM134B Antibody (YA6567)
(Synonyms: Reticulophagy regulator 1 RETREG1 Reticulophagy receptor 1 FAM134B JK1)FAM134B Antibody (YA6567) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAM134B.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 |
Product Details
FAM134B Antibody (YA6567) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAM134B.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 55 kDa
Recombinant protein within human FAM134B aa 318-497 / 497.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FAM134B is an Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions. Required for collagen quality control in a LIR motif-dependent manner. Required for long-term survival of nociceptive and autonomic ganglion neurons |(Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein. This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection[1][2][3][4][5].
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Subcellular Localization
Golgi apparatus, cis-Golgi network membrane,Endoplasmic reticulum membrane,Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Overexpressed in esophageal squamous cell carcinoma (PubMed:17487424) -
Isoforms & Post-Translational Modification
Q9H6L5 has 2 isomers: Q9H6L5-1: 54681 Da (predicted); Q9H6L5-2: 39317 Da (predicted).
Phosphorylation at Ser-151 by CAMK2B enhances oligomerization and membrane scission and reticulophagy activity -
Subunit
Homooligomer; oligomerization is enhanced following endoplasmic reticulum stress and is mediated by the reticulon homology domain (PubMed:31930741)
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SwissProt ID
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Synonyms
Reticulophagy regulator 1 RETREG1 Reticulophagy receptor 1 FAM134B JK1
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