Fibulin 5 Antibody (YA4555)
(Synonyms: EVEC; UP50; ARMD3; DANCE)Fibulin 5 Antibody (YA4555) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fibulin 5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
Fibulin 5 Antibody (YA4555) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fibulin 5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 50 kDa
Purified recombinant fragment of FBLN5 (aa242-448) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Fibulin 5 is essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells tH2O2gh interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN[1][2][3].
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Subcellular Localization
Secreted; Secreted, extracellular space, extracellular matrix
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Expression
Tissue_specificity:It is expressed in skin fibroblasts (protein level) (PubMed: 17035250) . It is primarily expressed in the heart, ovaries, and colon, but also found in the kidneys, pancreas, testes, lungs, and placenta. It has not been detected in the brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed: 10428823) . -
Subunit
Homodimer (PubMed:20007835). Monomer (PubMed:15790312, PubMed:19617354), homodimerizes in presence of Ca(2+) (PubMed:19617354). Interacts with ELN (PubMed:15790312, PubMed:17035250). Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1 (By similarity). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (PubMed:17255108). Interacts with EFEMP2 with moderate affinity (PubMed:19570982). Interacts with LOXL1 (By similarity)
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SwissProt ID
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Synonyms
EVEC; UP50; ARMD3; DANCE
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