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FHL2 Antibody (YA1875)

(Synonyms: AAG11; DRAL; Fhl2; SLIM3)
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FHL2 Antibody (YA1875) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FHL2.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • FHL2 Antibody (YA1875) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:1000-1:2000 1:50-1:200 1:20

Product Details

Description

FHL2 Antibody (YA1875) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FHL2.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 32 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 32 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human FHL2 aa20-279.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    FHL2 may function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes[1].

  • Subcellular Localization

    Cytoplasm; Nucleus; Cytoplasm, myofibril, sarcomere, Z line

  • Expression


    Tissue_specificity:Expressed in skeletal muscle and heart

  • Isoforms & Post-Translational Modification

    FHL2 has 2 isomers: Q14192-1: 32193 Da (predicted); Q14192-2: 15890 Da (predicted).

  • Subunit

    Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7.

  • SwissProt ID

    Q14192

  • Gene ID
    2274 [NCBI]
  • Synonyms

    AAG11; DRAL; Fhl2; SLIM3

  • Research Field

    Epigenetics and Nuclear Signaling

References

[1]. Dierck F, et al. The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling. J Biol Chem. 2017 Sep 15;292(37):15180-15191. [Content Brief]

FHL2 Antibody (YA1875) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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