Fibulin 5 Antibody (YA4555)(PBS only)

Cat. No.: HY-P84858A: Data Sheet User Guide for Antibodies
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Fibulin 5 Antibody (YA4555) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fibulin 5.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명
References

제품 설명

Fibulin 5 Antibody (YA4555) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fibulin 5.

Host

Mouse

분자량

Predicted band size: 50 kDa;

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9UBX5

Gene ID

10516 [NCBI]

Immunogen

Purified recombinant fragment of FBLN5 (aa242-448) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells tH2O2gh interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108)

Subcellular Localization：Secreted; Secreted, extracellular space, extracellular matrix

Expression：
Tissue_specificity:It is expressed in skin fibroblasts (protein level) (PubMed: 17035250) . It is primarily expressed in the heart, ovaries, and colon, but also found in the kidneys, pancreas, testes, lungs, and placenta. It has not been detected in the brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed: 10428823) .

Subunit：Homodimer (PubMed:20007835). Monomer (PubMed:15790312, PubMed:19617354), homodimerizes in presence of Ca(2+) (PubMed:19617354). Interacts with ELN (PubMed:15790312, PubMed:17035250). Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1 (By similarity). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (PubMed:17255108). Interacts with EFEMP2 with moderate affinity (PubMed:19570982). Interacts with LOXL1 (By similarity)

Synonyms

EVEC; UP50; ARMD3; DANCE

각종 서류

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/nci-h2405-cell.html