VEGF Receptor 1 Antibody (YA6239)

Cell membrane; Single-pass type I membrane protein; Endosome; Secreted; Secreted; Secreted; Cytoplasm; Cytoplasm; Cytoplasm

Tissue_specificity:It can be detected in normal lung tissue, as well as in the placenta, liver, kidneys, heart, and brain. It is primarily expressed in most vascular endothelial cells and also in peripheral blood mononuclear cells. Isomer 2 is highly expressed in the placenta. Isomer 3 is expressed in corneal epithelial cells (protein level) . Isomer 3 is expressed in vascular smooth muscle cells (VSMCs) .

Induction:Up-regulated in coculture of VSMC/endothelial cell (EC) or by direct exposure to VEGF of VSMC monoculture. Up-regulated from the second trimester of pregnancy to the term and in the placenta of women with preeclampsia (PE) . Up-regulated in monocytes exposed to bacterial lipopolysaccharide (LPS)

P17948 has 8 isomers: P17948-1: 150769 Da (predicted); P17948-2: 77474 Da (predicted); P17948-3: 82124 Da (predicted); P17948-4: 60917 Da (predicted); P17948-5: 62954 Da (predicted); P17948-6: 52613 Da (predicted); P17948-7: 39148 Da (predicted); P17948-8: 41175 Da (predicted).
N-glycosylated;Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation;Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB

Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR. Interacts (when tyrosine phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably also interacts with PTPRB. Interacts with RACK1. Identified in a complex with CBL and CD2AP

P17948

Vascular endothelial growth factor receptor 1; VEGFR-1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor;