FOXP2 Antibody (YA3528)
(Synonyms: SPCH1; CAGH44; TNRC10)FOXP2 Antibody (YA3528) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FOXP2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
FOXP2 Antibody (YA3528) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FOXP2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 70-80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 80 kDa
Purified recombinant fragment of human FOXP2 (AA: 641-740) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FOXP2 belongs to the forkhead box protein P (FOXP) family. FOXP2 is highly expressed in the nervous system and regulate molecular pathways required for proper brain development and function. FOXP2 is essential in growth arrest of 143 osteosarcoma cells via p21 activation. FOXP2 suppresses the transcriptional activity of target genes through the Zinc finger domain and also binds to domain for C-Terminal Binding Protein-1 (CtBP1) for suppressing E-cadherin and promoting invasion. The downregulation of FOXP2 enhances tumor initiation in breast cancers as a putative tumor/metastasis suppressor. Also, FOXP2 is downregulated in hepatocellular carcinoma (HCC) tumor tissues. Furthermore, FOXP2 is regarded as a SUMO target protein at cellular level, since FOXP2 is covalently modulated by both SUMO1 and SUMO3. SUMOylation of FOXP2 is significantly disturbed by a specific SUMO Specific Protease 2 (SENP2), since SUMOylation modulates transcriptional activity of FOXP2 in targeting downstream target genes (DISC1, SRPX2, and MiR200c) by reporter gene assay[1][2].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Isomer 1 and isomer 6 are expressed in the human brain, caudate nucleus, and lungs. -
Isoforms & Post-Translational Modification
O15409 has 9 isomers: O15409-1: 79919 Da (predicted); O15409-3: Da (predicted); O15409-2: 70104 Da (predicted); O15409-4: 82565 Da (predicted); O15409-5: 18315 Da (predicted); O15409-6: 48764 Da (predicted); O15409-7: 40969 Da (predicted); O15409-8: 9377 Da (predicted); O15409-9: 81840 Da (predicted).
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Subunit
Forms homodimers and heterodimers with FOXP1 and FOXP4. Isoform 1 and isoform 3 interact with TBR1 (PubMed:25232744, PubMed:30250039). Interacts with ZMYM2 (PubMed:32891193)
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SwissProt ID
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Synonyms
SPCH1; CAGH44; TNRC10
Documentation
[1]. Kim JH, et al. Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression. Mol Cancer. 2019 Dec 9;18(1):180. [Content Brief]
[2]. Co M, et al. FOXP transcription factors in vertebrate brain development, function, and disorders. Wiley Interdiscip Rev Dev Biol. 2020 Sep;9(5):e375. [Content Brief]
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