2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. GABA A Receptor alpha 5 Antibody (YA2249)

GABA A Receptor alpha 5 Antibody (YA2249)

Art. -Nr.: HY-P82504
User Guide for Antibodies Technical Support

GABA A Receptor alpha 5 Antibody (YA2249) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GABA A Receptor alpha 5.

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20 μL Angebot einholen 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
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100 μL Angebot einholen 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

Beschreibung

GABA A Receptor alpha 5 Antibody (YA2249) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GABA A Receptor alpha 5.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molekulargewicht
Predicted band size: 52 kDa;
Observed band size: 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human GABA A Receptor alpha 5 aa1-200.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Sensitivity Endogenous Reinheit Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:29961870, PubMed:30140029, PubMed:31056671). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30140029). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:30140029). GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity)
Subcellular Localization：Postsynaptic cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein
Subunit：Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties
Database

Entrez Gene: 2558 Human ; 110886 Mouse ; 29707 Rat

SwissProt: P31644 Human ; Q8BHJ7 Mouse ; P19969 Rat

OMIM: 618559 Human

Research Field

Neuroscience
Synonyms
GAA 5; GAA5; GABRA 5; Gabra5
Dokumentation
User Guide for Antibodies (1077 KB)

GABA A Receptor alpha 5 Antibody (YA2249) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GABA A Receptor alpha 5 Antibody (YA2249)
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