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GABARAP Antibody (YA7232)

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GABARAP Antibody (YA7232) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GABARAP.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, ELISA

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

  • Conjugation:
    Non-conjugated
  • GABARAP Antibody (YA7232) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-2000 1:5000-10000

Product Details

Description

GABARAP Antibody (YA7232) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GABARAP.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse Predicted Reactivity: Rat,Rabbit,Cow
    Info
    Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
  • Calculated Molecular Weight Predicted band size: 14 kDa;
Immunogen

Recombinant human GABARAP protein

Sensitivity

Endogenous

Purification

affinity purified by Protein G

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    GABARAP is an Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. Involved in apoptosis[1][2][3][4][5][6][7].

  • Subcellular Localization

    Cytoplasmic vesicle, autophagosome membrane,Endomembrane system,Cytoplasm, cytoskeleton,Golgi apparatus membrane,Cytoplasmic vesicle

  • Expression


    Tissue_Specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas

  • Isoforms & Post-Translational Modification

    O95166: 117 amino acids, molecular weight 13918 Da.

  • Subunit

    Interacts with GPHN and NSF (By similarity)

  • SwissProt ID

    O95166

GABARAP Antibody (YA7232) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • GABARAP Antibody (YA7232) Product Image
    1/16
  • GABARAP Antibody (YA7232) Product Image