GABARAP Antibody (YA7232)

Cat. No.: HY-P87548: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

GABARAP Antibody (YA7232) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GABARAP.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GABARAP Antibody (YA7232) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GABARAP.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 14 kDa;

Species Reactivity

Human, Mouse Predicted Reactivity: Rat,Rabbit,Cow

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

O95166

Immunogen

Recombinant human GABARAP protein

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-10000

Sensitivity	Endogenous	Purity	affinity purified by Protein G
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205). Involved in apoptosis (PubMed:15977068)

Subcellular Localization：Cytoplasmic vesicle, autophagosome membrane,Endomembrane system,Cytoplasm, cytoskeleton,Golgi apparatus membrane,Cytoplasmic vesicle

Expression：
Tissue_Specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas

Isoforms & Post-Translational Modification：O95166: 117 amino acids, molecular weight 13918 Da.

Subunit：Interacts with GPHN and NSF (By similarity)

Documentation

Select Batch:

Data Sheet (231 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)