HGS Antibody (YA7763)(PBS only)

Cat. No.: HY-P88079A: Data Sheet User Guide for Antibodies
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HGS Antibody (YA7763) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HGS.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

HGS Antibody (YA7763) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HGS.

Host

Mouse

Molecular Weight

Predicted band size: 86 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O14964

Immunogen

Full length human recombinant protein of human HGS produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation

Subcellular Localization：Cytoplasm,Early endosome membrane,Endosome, multivesicular body membrane

Expression：
Tissue_Specificity: Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes

Isoforms & Post-Translational Modification：O14964 has two isomers: O14964-1: 86192 Da (predicted); O14964-2: 76376 Da (predicted).
Phosphorylated on Tyr-334丨Ubiquitinated (PubMed:25588945)

Subunit：Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS

Synonyms

HRS

Documentation

User Guide for Antibodies (1077 KB)