HIP1 Antibody (YA1523)
(Synonyms: HIP 1; hip1; HIP1/PDGFRB fusion gene; HIPI; Huntingtin interacting protein 1)HIP1 Antibody (YA1523) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 | 1:30 |
Product Details
HIP1 Antibody (YA1523) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIP1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 116 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 116 kDa
Entrez Gene: 3092 Human ; 215114 Mouse ; 192154 Rat
SwissProt: O00291 Human ; Q8VD75 Mouse ;
OMIM: 601767 Human
A synthesized peptide derived from human HIP1 aa970-1037/1037.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HIP1 plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors[1][2][3][4][5][6][7][8].
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Subcellular Localization
Cytoplasm; Nucleus; Endomembrane system; Cytoplasmic vesicle, clathrin-coated vesicle membrane
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Expression
Tissue_specificity:Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer -
Isoforms & Post-Translational Modification
O00291 has 4 isomers: O00291-1: 116221 Da (predicted); O00291-2: Da (predicted); O00291-3: 110663 Da (predicted); O00291-4: 113076 Da (predicted).
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Subunit
Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N-terminus). Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts with GRIA1, GRIN2A and GRIN2B
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SwissProt ID
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Synonyms
HIP 1; hip1; HIP1/PDGFRB fusion gene; HIPI; Huntingtin interacting protein 1
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Research Field
Neuroscience
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