HIPK1 Antibody (YA8185)
(Synonyms: Myak; Nbak2)HIPK1 Antibody (YA8185) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIPK1.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
HIPK1 Antibody (YA8185) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIPK1.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 87.1 kDa
Human recombinant protein fragment corresponding to amino acids 439-697 of human HIPK1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
HIPK1 is a Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN[1].
-
Subcellular Localization
Nucleus,Cytoplasm,Nucleus speckle
-
Expression
Tissue_Specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. Expressed in both androgen-dependent and androgen-independent prostate cancer cells (PubMed:28289210) -
Isoforms & Post-Translational Modification
Q86Z02 has four isomers: Q86Z02-1: 130843 Da (predicted); Q86Z02-2: 116731 Da (predicted); Q86Z02-3: 89481 Da (predicted); Q86Z02-4: 87302 Da (predicted).
Autophosphorylated丨Degraded by PARK7 at the protein level丨Sumoylated -
Subunit
Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53
-
SwissProt ID
-
Synonyms
Myak; Nbak2
Documentation
Powered by Bioz
