IFN gamma Antibody (YA4903)
(Synonyms: IFNG; Interferon gamma; IFN-gamma; Immune interferon)IFN gamma Antibody (YA4903) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IFN gamma.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH7.4)with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-800 | 1:10000 |
Product Details
IFN gamma Antibody (YA4903) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IFN gamma.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 19 kDa;
Recombinant protein of human IFN-γ.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4)with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IFN-γ (Interferon-gamma) is a key immune cytokine produced by NK cells, Th1 cells, and CD8⁺ T cells. It regulates macrophage activation, Th1 differentiation, antigen presentation, and anti-tumor immunity via the IFNGR-JAK-STAT1 pathway. IFN-γ serves as an important indicator for assessing cellular immune function, T-cell activation status, and the efficacy of immunotherapy.
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:Mainly released by activated T lymphocytes
Induction:By cytokines, most notably interleukin IL-12, secreted by professional antigen-presenting cells such as monocytes/macrophages and dendritic cells -
Subunit
Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization
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SwissProt ID
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Synonyms
IFNG; Interferon gamma; IFN-gamma; Immune interferon
Documentation
References
[1]. El Bougrini J, et al. Arsenic enhances the apoptosis induced by interferon gamma: key role of IRF-1. Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):9-15. [Content Brief]
[2]. Hisamatsu H, et al. Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. J Exp Med. 1996 Apr 1;183(4):1807-16. [Content Brief]
[3]. Greenlund AC, et al. Interferon-gamma induces receptor dimerization in solution and on cells. J Biol Chem. 1993 Aug 25;268(24):18103-10. [Content Brief]
[4]. Akiyama K, et al. Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing. FEBS Lett. 1994 Apr 18;343(1):85-8. [Content Brief]
[5]. Fabunmi RP, et al. Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies. J Cell Sci. 2001 Jan;114(Pt 1):29-36. [Content Brief]
[6]. Lah TT, et al. Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett. 1995 Apr 17;363(1-2):85-9. [Content Brief]
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