IFT57 (HIPPI) Antibody (YA8300)(PBS only)

Cat. No.: HY-P88616A: Data Sheet User Guide for Antibodies
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IFT57 (HIPPI) Antibody (YA8300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IFT57 (HIPPI).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

IFT57 (HIPPI) Antibody (YA8300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IFT57 (HIPPI).

Host

Mouse

Molecular Weight

Predicted band size: 49.1 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NWB7

Immunogen

Full length human recombinant protein of human IFT57 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-250
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Shipping

Shipping with blue ice.

Background

Function：Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

Subcellular Localization：Cell projection, cilium,Cytoplasm, cytoskeleton, cilium basal body

Expression：
Tissue_Specificity: Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level)

Isoforms & Post-Translational Modification：Q9NWB7: 429 amino acids, molecular weight 49108 Da.

Subunit：Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity)

Synonyms

ESRRBL1; HIPPI; MHS4R2

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/kb-cell.html [Content Brief]