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Cat. No.: HY-P86746

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IKB alpha Antibody (YA6438)

Name: IKB alpha Antibody (YA6438)
Brand: MedChemExpress
SKU: HY-P86746
Price: 120.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: NFKBIA; Inhibitor of KB alpha; I kappa B alpha; I(Kappa)B(alpha); IkappaBalpha; IKBA; IKBalpha; MAD 3; MAD3; Major histocompatibility complex enhancer binding protein MAD3; NF kappa B inhibitor alpha; NFKBI; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha; IKBA_HUMAN.)

IKB alpha Antibody (YA6438) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IKB alpha.

For research use only. We do not sell to patients.

Host:
Mouse
Isotype:
IgG1
Application:
WB, IHC-P, IHC-F, IF-Tissue, ICC/IF
Reactivity :
Human, Rat

Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
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- Storage & Stability
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Background
Documentation
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Classifications
Bioz

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:500-2000	1:100-500	1:100-500	1:100-500	1:50-1:200

Product Details

Description

IKB alpha Antibody (YA6438) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IKB alpha.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human, Rat
Calculated Molecular Weight Predicted band size: 36 kDa

Immunogen

Recombinant human IKB alpha Protein aa 1-77/314

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

Appearance

Liquid
Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

IKB alpha inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription^[1]^[2]^[3]^[4]^[5]^[6].
Subcellular Localization

Cytoplasm,Nucleus
Expression

Induction: Induced in adherent monocytes
Subunit

Interacts with RELA; the interaction requires the nuclear import signal (PubMed:1493333)
SwissProt ID

P25963
Gene ID

4792 [NCBI]
Synonyms

NFKBIA; Inhibitor of KB alpha; I kappa B alpha; I(Kappa)B(alpha); IkappaBalpha; IKBA; IKBalpha; MAD 3; MAD3; Major histocompatibility complex enhancer binding protein MAD3; NF kappa B inhibitor alpha; NFKBI; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha; IKBA_HUMAN.