INPP4A Antibody (YA6606)
(Synonyms: 107kDa antibody; 4-bisphosphate 4-phosphatase antibody; 9630012D15 antibody; D130048C09Rik antibody; Inositol polyphosphate 4 phosphatase type I 107kDa antibody; Inositol polyphosphate 4 phosphatase type I antibody; Inositol polyphosphate 4-phosphatase type I antibody; INP4A_HUMAN antibody; INPP4 antibody; Inpp4a antibody; 107kDa antibody; 4-bisphosphate 4-phosphatase antibody; 9630012D15 antibody; D130048C09Rik antibody; Inositol polyphosphate 4 phosphatase type I 107kDa antibody; Inositol polyphosphate 4 phosphatase type I antibody; Inositol polyphosphate 4-phosphatase type I antibody; INP4A_HUMAN antibody; INPP4 antibody; Inpp4a antibody; OTTHUMP00000203138 antibody; OTTHUMP00000203139 antibody; OTTHUMP00000203141 antibody; OTTHUMP00000225217 antibody; R74740 antibody; TVAS1 antibody; Type I inositol 3 4 bisphosphate 4 phosphatase antibody; Type I inositol 3,4 bisphosphate 4 phosphatase antibody; Type I inositol-3 antibody; )INPP4A Antibody (YA6606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to INPP4A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:200 | 1:100 |
Product Details
INPP4A Antibody (YA6606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to INPP4A.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 110 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 110 kDa
Recombinant protein within human INPP4A aa 1-250 / 977.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
INPP4A catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current|Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3[1][2][3].
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Subcellular Localization
Early endosome membrane,Recycling endosome membrane,Cell membrane,Nucleus,Cytoplasm,Postsynaptic density
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Expression
Tissue_Specificity: Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain -
Isoforms & Post-Translational Modification
Q96PE3 has four isomers: Q96PE3-1: 109956 Da (predicted); Q96PE3-2: 105699 Da (predicted); Q96PE3-3: 109344 Da (predicted); Q96PE3-4: 107297 Da (predicted).
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Subunit
Interacts with INPP5F
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SwissProt ID
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Synonyms
107kDa antibody; 4-bisphosphate 4-phosphatase antibody; 9630012D15 antibody; D130048C09Rik antibody; Inositol polyphosphate 4 phosphatase type I 107kDa antibody; Inositol polyphosphate 4 phosphatase type I antibody; Inositol polyphosphate 4-phosphatase type I antibody; INP4A_HUMAN antibody; INPP4 antibody; Inpp4a antibody; 107kDa antibody; 4-bisphosphate 4-phosphatase antibody; 9630012D15 antibody; D130048C09Rik antibody; Inositol polyphosphate 4 phosphatase type I 107kDa antibody; Inositol polyphosphate 4 phosphatase type I antibody; Inositol polyphosphate 4-phosphatase type I antibody; INP4A_HUMAN antibody; INPP4 antibody; Inpp4a antibody; OTTHUMP00000203138 antibody; OTTHUMP00000203139 antibody; OTTHUMP00000203141 antibody; OTTHUMP00000225217 antibody; R74740 antibody; TVAS1 antibody; Type I inositol 3 4 bisphosphate 4 phosphatase antibody; Type I inositol 3,4 bisphosphate 4 phosphatase antibody; Type I inositol-3 antibody;
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