KATNA1 Antibody (YA7336)

Cat. No.: HY-P87652: Fiche technique User Guide for Antibodies
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Technical Support

KATNA1 Antibody (YA7336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KATNA1.

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Size		Stock
50 μL		Obtenir un devis
100 μL		Obtenir un devis

* Veuillez sélectionner la quantité avant d'ajouter des articles.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Description

Description

KATNA1 Antibody (YA7336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KATNA1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Masse moléculaire

Predicted band size: 56 kDa;

Observed band size: 56 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O75449

Immunogen

A synthesized peptide derived from human p60 Katanin

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-200

Sensitivity	Endogenous	Pureté	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Livraison

Shipping with blue ice.

Background

Function：Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth

Subcellular Localization：Cytoplasm,Midbody,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Cytoplasm, cytoskeleton, spindle pole,Cytoplasm, cytoskeleton, spindle

Isoforms & Post-Translational Modification：O75449 has two isomers: O75449-1: 55965 Da (predicted); O75449-2: 35319 Da (predicted).
Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation丨Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation

Subunit：Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules

Documentation

User Guide for Antibodies (1077 KB)