KATNA1 Antibody (YA7336)
(Synonyms: Katanin p60 ATPase-containing subunit A1, Katanin p60 subunit A1, p60 katanin, KATNA1)
Based on 1 Customer Validation
KATNA1 Antibody (YA7336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KATNA1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ICC/IF
-
Reactivity :
Human
-
Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
KATNA1 Antibody (YA7336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KATNA1.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 56 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 56 kDa
A synthesized peptide derived from human p60 Katanin: 465-491.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
KATNA1 is a Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth
-
Subcellular Localization
Cytoplasm,Midbody,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Cytoplasm, cytoskeleton, spindle pole,Cytoplasm, cytoskeleton, spindle
-
Isoforms & Post-Translational Modification
O75449 has two isomers: O75449-1: 55965 Da (predicted); O75449-2: 35319 Da (predicted).
Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation丨Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation -
Subunit
Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules
-
SwissProt ID
-
Synonyms
Katanin p60 ATPase-containing subunit A1, Katanin p60 subunit A1, p60 katanin, KATNA1
Documentation
Powered by Bioz
