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KBTBD7 Antibody (YA8117)(PBS only)

(Synonyms: DKFZp434E2318)

KBTBD7 Antibody (YA8117) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KBTBD7.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    ICC/IF

  • Reactivity :

    Human, Dog, Rat, Monkey, Mouse

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • KBTBD7 Antibody (YA8117)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:100-250

Product Details

Description

KBTBD7 Antibody (YA8117) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KBTBD7.

  • Host Mouse
  • Species Reactivity
    Human, Dog, Rat, Monkey, Mouse
  • Calculated Molecular Weight Predicted band size: 77.0 kDa
Immunogen

Full length human recombinant protein of human KBTBD7 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    KBTBD7 is an As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex[1].

  • Subcellular Localization

    Cytoplasm,Nucleus

  • Isoforms & Post-Translational Modification

    Q8WVZ9: 684 amino acids, molecular weight 77163 Da.

  • Subunit

    Core component of a BCR3 (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, also named Cul3-RING ubiquitin ligase complex CUL3(KBTBD6/7), composed of CUL3, RBX1, KBTBD6 and KBTBD7 (PubMed:25684205)

  • SwissProt ID

    Q8WVZ9

  • Synonyms

    DKFZp434E2318

KBTBD7 Antibody (YA8117)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • KBTBD7 Antibody (YA8117)(PBS only) Product Image
    1/16
  • KBTBD7 Antibody (YA8117)(PBS only) Product Image