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KSHV K8a Antibody (YA4606)(PBS only)

(Synonyms: K8)

KSHV K8a Antibody (YA4606) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KSHV K8a.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    WB, ICC/IF, ELISA

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • KSHV K8a Antibody (YA4606)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:25-1:50 ELISA: 1:10000

Product Details

Description

KSHV K8a Antibody (YA4606) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KSHV K8a.

  • Host Mouse
Immunogen

Purified recombinant fragment of KSHV K8α aa 34-199.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    KSHV K8a is a SUMO E3 ligase that plays a role in viral gene regulation and is essential for viral reactivation. Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 and RB1. Regulates viral gene expression and reactivation and may mediate the SUMOylation of viral promoters in the low methylated 'Lys-9' histone H3 (H3K9me) region which results in a diminution of viral gene expression after reactivation. SUMOylates also host histone lysine demethylase 4A/KDM4A, an essential step for complete enrichment of SUMO-2/3 on the viral genome during viral transactivation and reactivation[1][2][3][4].

  • Subunit

    Interacts with host HDAC1 and HDAC2, these interactions suppress HDAC activities. Interacts with protein ORF57. Interacts with protein vPK (PubMed:17108053)

  • SwissProt ID

    Q2HR82

  • Gene ID
    4961462 [NCBI]
  • Synonyms

    K8

KSHV K8a Antibody (YA4606)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • KSHV K8a Antibody (YA4606)(PBS only) Product Image