2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. KSHV K8a Antibody (YA4606)(PBS only)

KSHV K8a Antibody (YA4606)(PBS only)

Cat. No.: HY-P84909A
User Guide for Antibodies Technical Support

KSHV K8a Antibody (YA4606) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KSHV K8a.

For research use only. We do not sell to patients.

Size Stock
50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

KSHV K8a Antibody (YA4606) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KSHV K8a.
Host

Mouse
SwissProt ID
Gene ID
Immunogen

Purified recombinant fragment of KSHV K8α aa 34-199.
Application &
Dilution Ratio
Application Dilution Ratio
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:25-1:50 ELISA: 1:10000
Purity affinity purified. Conjugation Non-conjugated
Isotype IgG2a  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：SUMO E3 ligase that plays a role in viral gene regulation and is essential for viral reactivation (PubMed:17652396, PubMed:20034935). Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 and RB1. Regulates viral gene expression and reactivation and may mediate the SUMOylation of viral promoters in the low methylated 'Lys-9' histone H3 (H3K9me) region which results in a diminution of viral gene expression after reactivation (PubMed:26197391). SUMOylates also host histone lysine demethylase 4A/KDM4A, an essential step for complete enrichment of SUMO-2/3 on the viral genome during viral transactivation and reactivation (PubMed:28212444)
Subunit：Interacts with host HDAC1 and HDAC2, these interactions suppress HDAC activities. Interacts with protein ORF57. Interacts with protein vPK (PubMed:17108053)
Synonyms
K8
Documentation
User Guide for Antibodies (1077 KB)

KSHV K8a Antibody (YA4606)(PBS only) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KSHV K8a Antibody (YA4606)(PBS only)
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