BNP Antibody (YA999)
(Synonyms: NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide)BNP Antibody (YA999) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to BNP.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:10000 |
Product Details
BNP Antibody (YA999) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to BNP.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 30 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 15 kDa
Synthetic peptide derived from human NT-proBNP.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BNP is a Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3; May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32; May have a role in cardio-renal homeostasis. Able to promote the production of cGMP[1][2][3][4][5][6][7][8].
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Subcellular Localization
Secreted; Secreted; Secreted; Secreted
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Expression
Tissue_specificity:Protein levels were detected in the atria (PubMed: 2136732, PubMed: 2138890) . Protein levels were detected in the distal convoluted tubule cells of the kidney (PubMed: 9794555) . -
SwissProt ID
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Synonyms
NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide
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Research Field
Neuroscience
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