Nectin-3/CD113 Antibody
(Synonyms: CD113, PRR3, PVRL3, NECTIN3, Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3)Nectin-3/CD113 Antibody is a Rabbit-derived and non-conjugated IgG1 polyclonal antibody, targeting to Nectin-3/CD113.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS with 0.05% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:100-200 | 1:1000-2000 |
Product Details
Nectin-3/CD113 Antibody is a Rabbit-derived and non-conjugated IgG1 polyclonal antibody, targeting to Nectin-3/CD113.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 61kDa;
SwissProt: SwissProt: Q9NQS3
Purified recombinant protein of human CD113.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nectin-3/CD113 is a Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity)[1].
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Subcellular Localization
Cell membrane; Postsynaptic cell membrane; Cell junction, adherens junction
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Expression
Tissue_Specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. -
Isoforms & Post-Translational Modification
Nectin-3/CD113 has 3 isoforms, Q9NQS3-1: amino acid length is 549, molecular weight is 61002 Da (predicted); Q9NQS3-2: amino acid length is 366, molecular weight is 39692 Da (predicted); Q9NQS3-3: amino acid length is 487, molecular weight is 54375 Da (predicted).
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Subunit
Cis- and trans-homodimer.
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SwissProt ID
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Synonyms
CD113, PRR3, PVRL3, NECTIN3, Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3
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