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NNT Antibody (YA8938)

(Synonyms: Nicotinamide nucleotide transhydrogenase, Pyridine nucleotide transhydrogenase, NNT)
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NNT Antibody (YA8938) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NNT.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA

  • Reactivity :

    human, mouse, rat

  • Formulation:

    Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.

  • Conjugation:
    Non-conjugated
  • NNT Antibody (YA8938) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IF-Tissue Info
IF-Tissue: Immunofluorescence-Tissue
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:100-1000 1:50-500 1:50-500 1:100-500 1-2μg per 100-500μg Total protein 1:30-3000

Product Details

Description

NNT Antibody (YA8938) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NNT.

  • Host Mouse
  • Species Reactivity
    human, mouse, rat
  • Calculated Molecular Weight Predicted band size: 109 kDa
Species Reactivity Database

OMIM: 607878

Immunogen

A synthesized peptide derived from human NNT.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at 2-8°C for 1 year, do not freeze.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NNT is a The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland[1].

  • Subcellular Localization

    Mitochondrion inner membrane

  • Expression


    Tissue_Specificity: Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.

  • Isoforms & Post-Translational Modification

    NNT has an amino acid length of 1086, molecular weight is 113896 Da.

  • Subunit

    Homodimer

  • SwissProt ID

    Q13423

  • Gene ID
    23530 [NCBI]
  • Synonyms

    Nicotinamide nucleotide transhydrogenase, Pyridine nucleotide transhydrogenase, NNT

References

[1]. Meimaridou E, et al. Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Nat Genet. 2012 May 27;44(7):740-2. [Content Brief]

NNT Antibody (YA8938) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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