NrCAM Antibody (YA4402)(PBS only)

Cat. No.: HY-P84705A: Data Sheet User Guide for Antibodies
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NrCAM Antibody (YA4402) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NrCAM.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NrCAM Antibody (YA4402) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NrCAM.

Host

Mouse

Molecular Weight

Predicted band size: 144 kDa;

Observed band size: 144 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q92823

Gene ID

4897 [NCBI]

Immunogen

Purified recombinant fragment of human NRCAM (AA: 1192-1255) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50 ELISA: 1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Cell projection, axon; Secreted

Expression：
Tissue_specificity:The substance was detected in all examined tissues. In the brain, it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus.

Isoforms & Post-Translational Modification：Q92823 has 6 isomers: Q92823-1: 143890 Da (predicted); Q92823-2: 136614 Da (predicted); Q92823-3: 130668 Da (predicted); Q92823-4: 131046 Da (predicted); Q92823-5: 144375 Da (predicted); Q92823-6: 131744 Da (predicted).

Subunit：Constituent of a NFASC/NRCAM/ankyrin-G complex. Detected in a complex with CNTN1 and PTPRB. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC (PubMed:23897819)

Synonyms

NRCAM

Documentation

User Guide for Antibodies (1077 KB)