PALLD Antibody
(Synonyms: CDT6; Angiopoietin-related protein 7; Angiopoietin-like factor; Angiopoietin-like protein 7; Cornea-derived transcript 6 protein)PALLD Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PALLD.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
PALLD Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PALLD.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 122 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 150 kDa
Synthetic peptide corresponding to the center region of human PALLD.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PALLD is a Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci
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Subcellular Localization
Cytoplasm, cytoskeleton; Cell junction, focal adhesion; Cytoplasm, myofibril, sarcomere, Z line; Cell projection, ruffle; Cell projection, podosome; Cell projection, lamellipodium; Cell projection, axon; Cell projection, growth cone
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Expression
Tissue_Specificity: Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines.
Induction: Isoform 3 is expressed de novo. Isoform 4 is up-regulated by TGFB1 during myofibroblast differentiation. -
Isoforms & Post-Translational Modification
PALLD has 9 isoforms, Q8WX93-1: amino acid length is 1383, molecular weight is 150564 Da (predicted); Q8WX93-2: amino acid length is 1106, molecular weight is 122047 Da (predicted); Q8WX93-3: amino acid length is 1001, molecular weight is 108632 Da (predicted); Q8WX93-4: amino acid length is 672, molecular weight is 73322 Da (predicted); Q8WX93-5: amino acid length is 1159, molecular weight is 127826 Da (predicted); Q8WX93-6: amino acid length is 533, molecular weight is 58796 Da (predicted); Q8WX93-7: amino acid length is 385, molecular weight is 42933 Da (predicted); Q8WX93-8: amino acid length is 777, molecular weight is 85894 Da (predicted); Q8WX93-9: amino acid length is 1123, molecular weight is 123693 Da (predicted).主要在丝氨酸残基上发生磷酸化，酪氨酸残基上的磷酸化程度较低(根据相似性推断)。PKB/AKT1 介导的第 1118 位丝氨酸(Ser-1118)磷酸化会调控细胞骨架组装和细胞迁移PALLD 存在 9 个异构体，Q8WX93-1：氨基酸个数为 1383 个，分子量为 150564 Da (预测)；Q8WX93-2：氨基酸个数为 1106 个，分子量为 122047 Da (预测)；Q8WX93-3：氨基酸个数为 1001 个，分子量为 108632 Da (预测)；Q8WX93-4：氨基酸个数为 672 个，分子量为 73322 Da (预测)；Q8WX93-5：氨基酸个数为 1159 个，分子量为 127826 Da (预测)；Q8WX93-6：氨基酸个数为 533 个，分子量为 58796 Da (预测)；Q8WX93-7：氨基酸个数为 385 个，分子量为 42933 Da (预测)；Q8WX93-8：氨基酸个数为 777 个，分子量为 85894 Da (预测)；Q8WX93-9：氨基酸个数为 1123 个，分子量为 123693 Da (预测)。Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity). Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility
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Subunit
Interacts with EPS8 (By similarity).
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SwissProt ID
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Synonyms
CDT6; Angiopoietin-related protein 7; Angiopoietin-like factor; Angiopoietin-like protein 7; Cornea-derived transcript 6 protein
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