2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. PGP9.5 Antibody (YA5692)

PGP9.5 Antibody (YA5692)

製品番号: HY-P86000
User Guide for Antibodies Technical Support

PGP9.5 Antibody (YA5692) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGP9.5.

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

PGP9.5 Antibody (YA5692) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGP9.5.
Host

Mouse
Clonality

Monoclonal
分子量
Predicted band size: 25 kDa;
Observed band size: 25 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Synthesized peptide derived from human PGP 9.5 AA range: 100-223
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-400
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:500-5000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-200
純度 affinity chromatography. Conjugation Non-conjugated
Modification Unmodified Isotype IgG1
Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis (PubMed:22212137, PubMed:23359680). Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1 (PubMed:22212137, PubMed:25615526). In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways (PubMed:12408865, PubMed:8639624, PubMed:9774100). Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production (PubMed:22212137). Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes (By similarity). Mediates the 'Lys-48'-linked deubiquitination of the transcriptional coactivator WWTR1/TAZ leading to its stabilization and inhibition of osteoclastogenesis (By similarity). Deubiquitinates and stabilizes epidermal growth factor receptor EGFR to prevent its degradation and to activate its downstream mediators (By similarity). Modulates oxidative activity in skeletal muscle by regulating key mitochondrial oxidative proteins (By similarity). Enhances the activity of hypoxia-inducible factor 1-alpha/HIF1A by abrogateing its VHL E3 ligase-mediated ubiquitination and consequently inhibiting its degradation (PubMed:25615526)
Subcellular Localization：Cytoplasm; Endoplasmic reticulum membrane; Lipid-anchor
Expression：
Tissue_specificity:It has been found in both the cell bodies and processes of neocortical neurons (protein level) . It is expressed in neurons and cells of the diffuse neuroendocrine system and in tumors therein. Expression is weak in the ovary. It is downregulated in the brain tissue of Parkinson's disease and Alzheimer's disease.
Isoforms & Post-Translational Modification：P09936 has 3 isomers: P09936-1: 24824 Da (predicted); P09936-2: 24227 Da (predicted); P09936-3: 23513 Da (predicted).
O-glycosylated
Subunit：Monomer. Homodimer. Interacts with COPS5
ドキュメンテーション
User Guide for Antibodies (1077 KB)

PGP9.5 Antibody (YA5692) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
PGP9.5 Antibody (YA5692)
製品番号:
HY-P86000
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