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  4. Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies
  5. Phospho-Tau (Ser396) Antibody (YA7474)

Phospho-Tau (Ser396) Antibody (YA7474)

製品番号: HY-P87789
User Guide for Antibodies Technical Support

Phospho-Tau (Ser396) Antibody (YA7474) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-Tau (Ser396).

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Phospho-Tau (Ser396) Antibody (YA7474) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-Tau (Ser396).
Host

Rabbit
Clonality

Monoclonal,Recombinant
分子量
Predicted band size: 79 kDa;
Observed band size: 55-130 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Immunogen

The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-1:1000
WB
WB: Western Blot
1:2000-1:10000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:200-1:1000
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:5000-1:20000
Sensitivity Endogenous 純度 Protein A affinity purified
Conjugation Non-conjugated Modification Phosphorylated
Isotype IgG, Kappa  
Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization
Subcellular Localization：Cytoplasm, cytosol,Cell membrane,Cytoplasm, cytoskeleton,Cell projection, axon,Cell projection, dendrite,Secreted
Expression：
Tissue_Specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system
Isoforms & Post-Translational Modification：P10636 has 9 isomers: P10636-1: 78928 Da (predicted); P10636-2: 36760 Da (predicted); P10636-3: 32944 Da (predicted); P10636-4: 39720 Da (predicted); P10636-5: 42603 Da (predicted); P10636-6: 40007 Da (predicted); P10636-7: 42967 Da (predicted); P10636-8: 45850 Da (predicted); P10636-9: 80941 Da (predicted).
Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in the form associated with paired helical filaments (PHF-tau)), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3 or MARK4), causing detachment from microtubules, and their disassembly (PubMed:23666762, PubMed:7706316)丨Polyubiquitinated丨O-glycosylated丨Glycation of PHF-tau, but not normal brain TAU/MAPT
Subunit：Interacts with MARK1, MARK2, MARK3 and MARK4 (PubMed:23666762)
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Phospho-Tau (Ser396) Antibody (YA7474) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Phospho-Tau (Ser396) Antibody (YA7474)
製品番号:
HY-P87789
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