Polymeric immunoglobulin receptor/PIGR Antibody (YA7087)
Polymeric immunoglobulin receptor/PIGR Antibody (YA7087) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Polymeric immunoglobulin receptor/PIGR.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
Polymeric immunoglobulin receptor/PIGR Antibody (YA7087) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Polymeric immunoglobulin receptor/PIGR.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 83.3kDa;
SwissProt: SwissProt: P01833
Purified recombinant fragment of human PIGR (AA: extra 19-170) expressed in E. Coli.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Polymeric immunoglobulin receptor/PIGR mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment|Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells[1][2].
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Subcellular Localization
Cell membrane,Secreted
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Isoforms & Post-Translational Modification
P01833: 764 amino acids, molecular weight 83284 Da.
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Subunit
Interacts (mainly via CDR1-like domain) with dimeric IgA (PubMed:15530357)
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SwissProt ID
Documentation
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