PSMA Antibody (YA6005)

Cat. No.: HY-P86313: Data Sheet User Guide for Antibodies
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PSMA Antibody (YA6005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMA.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

PSMA Antibody (YA6005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMA.

Host

Rabbit

Clonality

Monoclonal

Molecular Weight

Predicted band size: 84 kDa;

Observed band size: 84 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q04609

Gene ID

2346 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
WB WB: Western Blot	1:2000-1:10000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-1:20000
IP IP: Immunoprecipitation	1:50-1:200

Purity	Protein A	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression; Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC

Subcellular Localization：Cell membrane; Single-pass type II membrane protein; Cytoplasm

Expression：
Tissue_specificity:It is highly expressed in prostate epithelial cells. It can be detected in the bladder, kidneys, testes, ovaries, fallopian tubes, breasts, adrenal glands, liver, esophagus, stomach, small intestine, colon, and brain (protein level) . It can also be detected in the capillary endothelial cells of the small intestine, brain, kidneys, liver, spleen, colon, trachea, spinal cord, and various tumors. It is specifically expressed in the brush border membrane of the jejunum. In the brain, it is highly expressed in the ventral striatum and brainstem. It is also expressed in fetal liver and kidneys. The PSMA' subtype is the most abundant subtype in normal prostate. The PSMA-1 subtype is the most abundant subtype in primary prostate tumors. The PSMA-9 subtype is specifically expressed in prostate cancer.

Induction:In the prostate, up-regulated in response to androgen deprivation

Isoforms & Post-Translational Modification：Q04609 has 8 isomers: Q04609-1: 84331 Da (predicted); Q04609-3: 78065 Da (predicted); Q04609-4: 27811 Da (predicted); Q04609-6: 78000 Da (predicted); Q04609-7: 82519 Da (predicted); Q04609-8: 80597 Da (predicted); Q04609-9: 78785 Da (predicted); Q04609-10: 50090 Da (predicted).
The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis;The N-terminus is blocked

Subunit：Homodimer

Documentation

User Guide for Antibodies (1077 KB)