PSMA Antibody (YA6005)
(Synonyms: FOLH, NAALAD1, PSM, PSMA, GIG27, FOLH1, Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetylated-alpha-linked acidic dipeptidase I, Prostate-specific membrane antigen, Pteroylpoly-gamma-glutamate carboxypeptidase, FGCP, GCPII, mGCP, NAALADase I)PSMA Antibody (YA6005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:2000-1:10000 | 1:200-1:1000 | 1:5000-1:20000 | 1:50-1:200 |
Product Details
PSMA Antibody (YA6005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMA.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 84 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 84 kDa
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PSMA is a transmembrane protein that anchores to the cell membrane through its transmembrane region and is mainly expressed in prostate epithelial cells but also exists in other tissues. PSMA exhibits glutamate-preferring carboxypeptidase activity that hydrolyzes polyglutamylated folic acid to release folic acid monomers. PSMA mediates the endocytosis on the cell surface. PSMA acts as an angiogenesis marker in cancer cells. PSMA can be used as a diagnostic marker for prostate cancer, and for detection of invasiveness and metastatic ability of the tumor[1].
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein; Cytoplasm
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Expression
Tissue_specificity:It is highly expressed in prostate epithelial cells. It can be detected in the bladder, kidneys, testes, ovaries, fallopian tubes, breasts, adrenal glands, liver, esophagus, stomach, small intestine, colon, and brain (protein level) . It can also be detected in the capillary endothelial cells of the small intestine, brain, kidneys, liver, spleen, colon, trachea, spinal cord, and various tumors. It is specifically expressed in the brush border membrane of the jejunum. In the brain, it is highly expressed in the ventral striatum and brainstem. It is also expressed in fetal liver and kidneys. The PSMA' subtype is the most abundant subtype in normal prostate. The PSMA-1 subtype is the most abundant subtype in primary prostate tumors. The PSMA-9 subtype is specifically expressed in prostate cancer.
Induction:In the prostate, up-regulated in response to androgen deprivation -
Isoforms & Post-Translational Modification
Q04609 has 8 isomers: Q04609-1: 84331 Da (predicted); Q04609-3: 78065 Da (predicted); Q04609-4: 27811 Da (predicted); Q04609-6: 78000 Da (predicted); Q04609-7: 82519 Da (predicted); Q04609-8: 80597 Da (predicted); Q04609-9: 78785 Da (predicted); Q04609-10: 50090 Da (predicted).
The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis;The N-terminus is blocked -
Subunit
Homodimer
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SwissProt ID
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Synonyms
FOLH, NAALAD1, PSM, PSMA, GIG27, FOLH1, Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetylated-alpha-linked acidic dipeptidase I, Prostate-specific membrane antigen, Pteroylpoly-gamma-glutamate carboxypeptidase, FGCP, GCPII, mGCP, NAALADase I
Documentation
References
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